Impact of Cyp2c19 Allele 17 Mutase on Clopidogrel Hyper-Responsiveness in Indonesian Patients with Ischemic Stroke

BACKGROUND: Ischemic stroke dominated up to 76% of the 101.5 million cases globally. One treatments for is secondary prevention by administering antiplatelet. Clopidogrel an add-on antiplatelet dual therapy (DAPT) regimen. In its metabolism, clopidogrel can show nature resistance and bleeding risk. Studies on have been widely put forward but not with bleeding. The study risk Asian races focused only East races. AIM: objective determine in Indonesian population correlation polymorphism CYP2C19 allele 17. METHODS: There were 112 participants this study. About 45.5% showed a normal response clopidogrel, 40.2% had All (100.0%) mutations 17, 47.3% being intermediate metabolizers. RESULTS: was significantly correlated (p: 0.02). has high from administration. CONCLUSION: Compared DAPT administration, be monotherapy prevention.